Chief Operating Officer
& Senior Vice President
of Chemistry

John DeMattei is the Chief Operating Officer and Senior Vice President of Chemistry at OnKure, Inc.  He is a pharmaceutical development expert with extensive experience developing small molecule and oligonucleotide therapeutics. During his career, Dr. DeMattei has provided leadership to numerous pharmaceutical development teams, contributing to more than 30 issued patents and publications, 25 INDs, 3 approved NDAs, and 1 approved BLA. Prior to joining OnKure, Dr. DeMattei served as the Senior Director of Oligonucleotide Technology at Dynavax Inc. Dr. DeMattei did his academic training in chemistry at the University of Illinois, UCLA, and Harvard.