Samuel Agresta is the Chief Medical Officer. Dr. Agresta brings over 15 years of extensive experience in global oncology drug development from IND to Phase 4 design and execution, approval, medical and regulatory affairs strategic planning.
Prior to joining OnKure, Dr. Agresta served as Foghorn Therapeutics, Inc.’s Chief Medical Officer. In that role, Dr. Agresta built Foghorn’s clinical development team and lead the team in three IND filings through Phase 1 development in acute myeloid leukemia, myelodysplastic syndrome, uveal melanoma, and synovial cell sarcoma. Dr. Agresta also served as a Director and Chief Medical Officer at Infinity Pharmaceuticals, Inc. where he was responsible for the Phase 1 and 2 developments of the PI3Ky inhibitor, IPI-549. Prior to his roles as Chief Medical Officer, Dr. Agresta served as Vice President and Head of Clinical Development at Agios Pharmaceuticals, Inc. where he was accountable for clinical oncology development and lead the FDA submissions for TIBSOVO® and IDIFA® in acute myeloid leukemia and myelodysplastic syndrome. Dr. Agresta also served as Senior Medical Director at Merrimack Pharmaceuticals, Inc. and Genentech, Inc. where he worked in the HER2 franchise.
Dr. Agresta received a B.S. from Georgetown University, an M.P.H. and T.M. from Tulane School of Public Health and Tropical Medicine, an M.D. from Tulane University Medical School and an M.S. in Clinical Investigation from the University of South Florida. He served his residency in Internal Medicine at Tulane University Health Science Center and completed a Fellowship in Hematology and Oncology at the Moffitt Cancer Center.