Pipeline

Program/TargetProg/Tgt
IndicationInd
DiscoveryDiscov
Lead
OptimizationLead Opt
IND
EnablingIND
Phase 1Ph 1
Phase 2Ph 2
CollaborationsCollab
Bocodepsin
NRAS Melanoma(1)
Bocodepsin
Oral, Selective Class I HDAC Inhibitor
NRAS Melanoma(1)
In combination w/ binimetinib
Nautilus Trial
Pfizer logo
Class I HDAC inhibition has been shown to dramatically enhance the efficacy of MEK inhibitors in Ras pathway driven melanomas by coordinately suppressing two DNA repair pathways. A potential clinical biomarker that predicts responsiveness has also been identified.
OKI-219
PI3K Alpha H1047R Mutated Cancer
OKI-219
Selective PI3K Alpha H1047R Inhibitor
PI3K Alpha H1047R Mutated Cancer
OKI-DISC-1
Undisclosed
OKI-DISC-1
Oncogenic Kinase Inhibitor
Undisclosed
OKI-DISC-2
Undisclosed
OKI-DISC-2
Oncogenic Kinase Inhibitor
Undisclosed

(1) Bocodepsin (OKI-179) Phase 2 first-in-human single agent trial previously completed.

(2) Pursuant to a Clinical Trial Collaboration and Supply Agreement with Pfizer for binimetinib/bocodepsin combination; OnKure retains all bocodepsin commercial rights.